r4.16xlarge

Memory optimized · r4 series · Intel Xeon E5-2686 v4 (Broadwell)

vCPU
64
Memory
488 GiB
Linux / hour
$4.26
Per month
$3,107
Per vCPU-hour
$0.0665
Per GiB-hour
$0.00872

Analysis

The r4.16xlarge is a memory optimized instance in the r4 series with 64 vCPUs and 488 GiB of memory on Intel Xeon E5-2686 v4 (Broadwell) (up to 2.3 GHz), which makes it memory-heavy at 7.62 GiB of memory per vCPU.

Running it in N. Virginia instead of São Paulo saves $3,434 a month per instance: $4.26/hour against $8.96/hour, a 111% spread.

On demand it costs $4.26/hour in US East (N. Virginia), $3,107 a month if left running, which puts it mid-table for memory optimized types at the 28th percentile per vCPU ($0.0665 per vCPU-hour) and the 47th percentile per GiB ($0.00872 per GiB-hour).

The newer r5.16xlarge on Intel Xeon Platinum 8175 is 5.3% cheaper at $4.03/hour, which makes the r4.16xlarge hard to justify for new deployments.

Looking beyond its own line, 12 of 39 current types with 64 vCPUs and similar memory are cheaper. The cheapest of those is the r6g.16xlarge on AWS Graviton2 at $3.23/hour.

It is the largest of the 6 r4 sizes. Dropping to the r4.8xlarge saves $1,553 a month.

Reserving it for a year with no upfront payment cuts the Linux rate to $2.69/hour, which beats on demand once it runs more than 63% of the time; three years brings it to $1.83/hour, 57% below on demand. Windows Server roughly adds 69% to the bill at $7.20/hour, because the licence is charged per vCPU.

Price by region (USD per hour)

RegionLinuxWindows1-yr RI3-yr RI
N. Virginia us-east-1$4.26$7.20$2.69$1.83
Ohio us-east-2$4.26$7.20$2.69$1.83
Oregon us-west-2$4.26$7.20$2.69$1.83
Canada Central ca-central-1$4.67$7.62$2.96$2.00
São Paulo sa-east-1$8.96$11.90$5.64$3.87
Ireland eu-west-1$4.74$7.69$2.99$2.04
London eu-west-2$4.99$7.94$3.16$2.14
Frankfurt eu-central-1$5.12$8.07$3.23$2.21
Mumbai ap-south-1$4.38$7.33$2.76$1.90
Singapore ap-southeast-1$5.12$8.06$3.23$2.21
Sydney ap-southeast-2$5.11$8.05$3.23$2.21
Tokyo ap-northeast-1$5.12$8.06$3.23$2.21

Shared tenancy, no pre-installed software. Reserved rates are standard, no upfront, per hour. Prices as of 2026-11-04.

Same shape, other types

TypevCPUMemory$/hourvs r4.16xlarge
r6g.16xlarge
AWS Graviton2 Processor
64512 GiB$3.23-24%
r7g.16xlarge
AWS Graviton3 Processor
64512 GiB$3.43-19%
r5a.16xlarge
AMD EPYC 7571
64512 GiB$3.62-15%
r6a.16xlarge
AMD EPYC 7R13 Processor
64512 GiB$3.63-15%
r6gd.16xlarge
AWS Graviton2 Processor
64512 GiB$3.69-13%
r8g.16xlarge
AWS Graviton4 Processor
64512 GiB$3.77-11%

Cost calculator

Specs

vCPU64
Memory488 GiB (7.6 per vCPU)
ProcessorIntel Xeon E5-2686 v4 (Broadwell)
Clock2.3 GHz
StorageEBS only
Network20 Gigabit

r4 sizes

r4.large2 vCPU$0.1330
r4.xlarge4 vCPU$0.2660
r4.2xlarge8 vCPU$0.5320
r4.4xlarge16 vCPU$1.06
r4.8xlarge32 vCPU$2.13
r4.16xlarge64 vCPU$4.26