r5n.16xlarge

Memory optimized · r5n series · Intel Xeon Platinum 8259 (Cascade Lake)

vCPU
64
Memory
512 GiB
Linux / hour
$4.77
Per month
$3,481
Per vCPU-hour
$0.0745
Per GiB-hour
$0.00931

Analysis

The r5n.16xlarge is a memory optimized instance in the r5n series with 64 vCPUs and 512 GiB of memory on Intel Xeon Platinum 8259 (Cascade Lake) (up to 2.5 GHz), which makes it memory-heavy at 8 GiB of memory per vCPU.

Within the same generation and size, the r5a.16xlarge on AMD EPYC 7571 costs $3.62/hour, 24% less ($841 a month). The other variants are the r5.16xlarge at $4.03, the r5ad.16xlarge at $4.19 and the r5d.16xlarge at $4.61.

Running it in N. Virginia instead of São Paulo saves $2,032 a month per instance: $4.77/hour against $7.55/hour, a 58% spread.

On demand it costs $4.77/hour in US East (N. Virginia), $3,481 a month if left running, which puts it mid-table for memory optimized types at the 40th percentile per vCPU ($0.0745 per vCPU-hour) and the 56th percentile per GiB ($0.00931 per GiB-hour).

Looking beyond its own line, 17 of 39 current types with 64 vCPUs and similar memory are cheaper. The cheapest of those is the r6g.16xlarge on AWS Graviton2 at $3.23/hour.

It is size 7 of 8 in the r5n series. Stepping up to the r5n.24xlarge gives 96 vCPUs and 768 GiB for $1,740 more a month. Dropping to the r5n.12xlarge saves $870 a month.

Price by region (USD per hour)

RegionLinuxWindows1-yr RI3-yr RI
N. Virginia us-east-1$4.77$7.71$3.00$1.93
Ohio us-east-2$4.77$7.71$3.00$1.93
Oregon us-west-2$4.77$7.71$3.00$1.93
Canada Central ca-central-1$5.22$8.16$3.29$2.02
São Paulo sa-east-1$7.55$10.50$4.76$3.11
Ireland eu-west-1$5.34$8.29$3.37$2.19
London eu-west-2$5.60$8.54$3.54$2.37
Frankfurt eu-central-1$5.70$8.64$3.59$2.35
Mumbai ap-south-1$4.90$7.84$3.08$1.98
Singapore ap-southeast-1$5.70$8.64$3.59$2.35
Sydney ap-southeast-2$5.79$8.74$3.65$2.35
Tokyo ap-northeast-1$5.79$8.74$3.65$2.38

Shared tenancy, no pre-installed software. Reserved rates are standard, no upfront, per hour. Prices as of 2026-11-04.

Same shape, other types

TypevCPUMemory$/hourvs r5n.16xlarge
r6g.16xlarge
AWS Graviton2 Processor
64512 GiB$3.23-32%
r7g.16xlarge
AWS Graviton3 Processor
64512 GiB$3.43-28%
r5a.16xlarge
AMD EPYC 7571
64512 GiB$3.62-24%
r6a.16xlarge
AMD EPYC 7R13 Processor
64512 GiB$3.63-24%
r6gd.16xlarge
AWS Graviton2 Processor
64512 GiB$3.69-23%
r8g.16xlarge
AWS Graviton4 Processor
64512 GiB$3.77-21%

Cost calculator

Specs

vCPU64
Memory512 GiB (8.0 per vCPU)
ProcessorIntel Xeon Platinum 8259 (Cascade Lake)
Clock2.5 GHz
StorageEBS only
Network75 Gigabit

r5n sizes

r5n.large2 vCPU$0.1490
r5n.xlarge4 vCPU$0.2980
r5n.2xlarge8 vCPU$0.5960
r5n.4xlarge16 vCPU$1.19
r5n.8xlarge32 vCPU$2.38
r5n.12xlarge48 vCPU$3.58
r5n.16xlarge64 vCPU$4.77
r5n.24xlarge96 vCPU$7.15